White Matter Hyperintensities and Cerebral Amyloidosis
نویسندگان
چکیده
منابع مشابه
White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease?
IMPORTANCE Current hypothetical models emphasize the importance of β-amyloid in Alzheimer disease (AD) pathogenesis, although amyloid alone is not sufficient to account for the dementia syndrome. The impact of small-vessel cerebrovascular disease, visualized as white matter hyperintensities (WMHs) on magnetic resonance imaging scans, may be a key factor that contributes independently to AD pres...
متن کاملCerebral hemodynamics and white matter hyperintensities in CADASIL.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small-vessel disease caused by mutations in the NOTCH3 gene on chromosome 19. On magnetic resonance imaging (MRI), subcortical white matter hyperintensities and lacunar infarcts are visualized. It is unknown whether a decrease in cerebral blood flow or cerebrovascular reactivity ...
متن کاملAttenuation of brain white matter hyperintensities after cerebral infarction.
Cerebral Infarction Brain white matter hyperintensities (WMHs) on MR imaging are reported to increase with age and do not decrease, though their pathogenesis is not well understood. Here, we report an interesting case in which a patient showed attenuation of WMHs at 1 year after the incidence of cerebral infarction. A 78-year-old female outpatient with hypertension and dyslipidemia presented wi...
متن کاملORIGINAL CONTRIBUTION White Matter Hyperintensities and Cerebral Amyloidosis Necessary and Sufficient for Clinical Expression of Alzheimer Disease?
Importance: Current hypothetical models emphasize the importance of -amyloid in Alzheimer disease (AD) pathogenesis, although amyloid alone is not sufficient to account for the dementia syndrome. The impact of smallvessel cerebrovascular disease, visualized as white matter hyperintensities (WMHs) on magnetic resonance imaging scans, may be a key factor that contributes independently to AD prese...
متن کاملMTI of white matter hyperintensities.
The severity of tissue changes associated with incidental white matter hyperintensities (WMH) in the elderly cannot be sufficiently determined by conventional MRI. We, therefore, performed a regional analysis of the magnetization transfer ratio (MTR) maps obtained on a 1.5 T scanner from 198 neurologically asymptomatic participants of the Austrian Stroke Prevention Study (mean age 70, age range...
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ژورنال
عنوان ژورنال: JAMA Neurology
سال: 2013
ISSN: 2168-6149
DOI: 10.1001/jamaneurol.2013.1321